DMD #8615 1 In Vitro P-glycoprotein Inhibition Assays for Assessment of Clinical Drug Interaction Potential of New Drug Candidates: A Recommendation for Probe Substrates

نویسندگان

  • Jarkko Rautio
  • Joan E. Humphreys
  • Lindsey O. Webster
  • Anand Balakrishnan
  • John P. Keogh
  • Jeevan R. Kunta
  • Cosette J. Serabjit-Singh
  • Joseph W. Polli
چکیده

Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC 27709 (J.R., J.E.H., L.O.W., A.B., C.J.S.S., J.W.P.), Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Ware, UK (J.P.K.); Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, PA 19406 (J.R.K.); and Department of Pharmaceutical Chemistry, University of Kuopio, P.O.Box 1627, FI-70211 Kuopio, Finland (J.R.) DMD Fast Forward. Published on February 7, 2006 as doi:10.1124/dmd.105.008615

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In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

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تاریخ انتشار 2006