DMD #8615 1 In Vitro P-glycoprotein Inhibition Assays for Assessment of Clinical Drug Interaction Potential of New Drug Candidates: A Recommendation for Probe Substrates
نویسندگان
چکیده
Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC 27709 (J.R., J.E.H., L.O.W., A.B., C.J.S.S., J.W.P.), Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Ware, UK (J.P.K.); Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, PA 19406 (J.R.K.); and Department of Pharmaceutical Chemistry, University of Kuopio, P.O.Box 1627, FI-70211 Kuopio, Finland (J.R.) DMD Fast Forward. Published on February 7, 2006 as doi:10.1124/dmd.105.008615
منابع مشابه
In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is anticipated that information regarding the potential interaction of drug candidates with Pgp will be a future regulatory expectation. Therefore, to be able to utilize in vitro Pgp inhibition findings to guid...
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